Bute for Horses

Bute for Horses

What is Bute Injectable 100 ml?
Phenylbutazone is a non-steroidal anti-inflammatory drug. It also has analgesic (pain relief) and antipyretic (fever-reducing) effects and is indicated for the treatment of a wide range of musculoskeletal disorders, including muscular sprain and strain, muscular overuse (including both muscular damage and strain/damage of the tendons attaching muscles to bone), tendonitis, acute joint injury/strain/sprain, and arthritic conditions.

Who is it for?
Horses

Why use it?
-For relief of inflammatory conditions associated with the musculoskeletal system in horse
-Control pain from injuries, infections, laminitis, or virtually any other source of pain

How it works?
The analgesic effect is related mainly to the compound’s anti-inflammatory properties.

Active ingredient(s):
Contains 200 mg phenylbutazone, 1.5% benzyl alcohol and purified water per ml.

How is it sold?
100 Ml Vials, 200 Mg/ml (1 G/5 Ml)

What are the side effects?
Stop medication at the first sign of gastrointestinal upset, jaundice, or blood dyscrasia. Authenticated cases of agranulocytosis associated with the drug have occurred in man; fatal reactions, although rare, have been reported in dogs after long-term therapy. To guard against this possibility, conduct routine blood counts at weekly intervals during the early phase of therapy and at intervals of two weeks thereafter. Any significant fall in the total white count, relative decrease in granulocytes, or black or tarry stools, should be regarded as a signal for immediate cessation of therapy and institution of appropriate countermeasures.

What special precautions are there?
Parenteral injections should be made intravenously only; do not inject subcutaneously or intramuscularly. Use with caution in patients who have a history of drug allergy.

What to do if overdose?
Contact your nearest emergency animal clinic.

How Can I store it?
Store In A Refrigerator Between 2°c And 8°c (36°f And 46°f).

Helpful Tips:
In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy is required.

How to use

Intravenously

1 to 2 g per 1,000 lbs of body weight (5 to 10 mL/1,000 lbs) daily. Injection should be given slowly and with care. Limit intravenous administration to a maximum of 5 successive days, which may be followed by oral phenylbutazone dosage forms.

Guidelines To Succesful Therapy

1. Use a relatively high dose for the first 48 hours, then reduce gradually to a maintenance dose. Maintain lowest dose capable of producing desired clinical response.

2. Response to phenylbutazone therapy is prompt, usually occurring within 24 hours. If no significant clinical response is evident after 5 days, reevaluate diagnosis and therapeutic approach.

3. In animals, phenylbutazone is largely metabolized in 8 hours. It is recommended that a third of the daily dose be administered at 8 hour intervals. Reduce dosage as symptoms regress. In some cases, treatment may be given only when symptoms appear with no need for continuous medication. If long-term therapy is planned, oral administration is suggested.

4. Many chronic conditions will respond to phenylbutazone therapy, but discontinuance of treatment may result in recurrence of symptoms.

What is in it?

Injection: For Horses Only: 100 Ml Vials, 200 Mg/ml (1 G/5 Ml)

Each mL contains 200 mg of phenylbutazone, 10.45 mg of benzyl alcohol as preservative, sodium hydroxide to adjust pH to 9.5 to 10.0, and water for injection, Q.S.

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Bromhexine Injection

Bromhexine Injection

DESCRIPTION- Ambroxal Injection is a Mucolytic expectorant to clear and maintain airways.


COMPOSITION-
Contains: Ambroxol hydrochloride 6 mg/mL

 

ACTIONS- AMBROXOL is a mucolytic expectorant. Ambroxol is an active metabolite of bromhexine, and acts to reduce the viscosity of tenacious mucus secretions by fragmentation of long mucopolysaccharide chains, resulting in a productive cough which aids expectoration of liquefied mucoid respiratory secretions, and assists in clearing and maintaining patent bronchioles and alveoli, hence reducing dyspnoea.
AMBROXOL enhances the concentrations of chemotherapeutic agents in bronchial secretions to result in a more rapid recovery.


INDICATIONS-
AMBROXOL is indicated to aid in the treatment of catarrhal inflammation of bronchi and the upper respiratory tract in horses and dogs. Specific indications include:
Chest Infections: acute and chronic bronchopneumonia, catarrhal rhinitis, strangles, post-viral cough
Uterine Infections: pyometron, mucometron
Ocular Infections: purulent conjunctivitis, hypopion.


FORM-
Sterile for injection


CATEGORY-


FOR-
Horses, Greyhounds, Dogs, Camels


DOSEAGE & ADMINISTRATION-
Horse: 0.3 mg/kg (5 mL/100 kg) bodyweight by intravenous injection twice daily.
Dogs: 0.6 mg/kg (1mL/10 kg) bodyweight by intravenous injection twice daily.
Administer AMBROXOL by intravenous injection.
It is safe to use AMBROXOL for extended periods.

PRESENTATION – 100 mL sterile multi-dose glass vial.


STORAGE
– Store below 25C (air conditioning). Protect from light.


AVAILABILTY
– For General Sale – APVMA Approval Number 51134


NOTES-
This product can be used with any other Vitamin or supplement from HorsePreRace.


WARNINGS
– Meat Withholding Period : Horses – 28 days.

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Blood Building Peptide

Blood Building Peptide 100ml

Blood Building Peptide is for rapidly increasing RBC & Hemoglobin in Race Horses & Camels.

Blood Building Peptide is an erythropoiesis-stimulating agent (ESA) that is being tested in clinical trials for the treatment of anemia associated with chronic renal failure (CRF). Trials are evaluating the ability of this peptide to correct anemia by raising and maintaining hemoglobin (Hgb) levels within a target of 10-12 or 11-12 g/dL, depending on the situation.

In contrast to the current standard of care, recombinant protein-based ESAs, Blood Building Peptide is a novel, synthetic peptide-based ESA that is immunologically distinct from endogenous human erythropoietin (EPO), a protein produced by the kidneys to stimulate the production of oxygen-transporting red blood cells. The most advanced portion of Blood Building Peptide clinical development program is an ongoing Phase 3 program that consists of four studies (two in dialysis, two in non-dialysis) involving approximately 2,600 patients across almost 400 clinical sites in U.S. and Europe. These and other well-designed studies in patients with CRF will not only evaluate Blood Building Peptide ability to manage patients’ Hgb with monthly dosing, but also the ability of Blood Building Peptide to maintain patients’ Hgb between the range of 11 to 12 g/dL in non-dialysis patients and 10-12 g/dL in dialysis patients.

While the development of pure red cell aplasia (PRCA) is listed as a potential adverse reaction to currently approved ESAs, Phase 2 Blood Building Peptide data have shown that Blood Building Peptide has the potential to increase and maintain Hgb levels in patients who have developed PRCA as a result of ESA use. PRCA is a rare condition in which the body develops neutralizing antibodies to recombinant ESAs that negate the effects of the ESA as well as the body’s naturally produced EPO. PRCA often leaves patients severely anemic and reliant on regularly administered blood transfusions and/or immunosuppressant therapy.

Actions – Increases red blood cells and Hgb

Indications – Horses with low blood count or anemia.

Form – Injectable/ oral use

Category – Blood Builders

For – Horses & Camels

Dosage and Administration
Adult Horses: 20 ml by intravenous oral use, four consecutive days not closer than 2 days to race, preferably start using 7 days prior to event for 4 consecutive days.

Presentation – 80 ml sterile multi-dose glass vial.

Storage- Store below 25 C (Air Conditioning). Protect from light. Shelf life 12 months. Use the contents of the vial within 3 months of initial broaching, and discard any unused portion.

Warnings – Precautions : Do not give intramuscular under any circumstance. Do not use two weeks consecutive

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Blast Off Distance 100mL

Blast Off Distance 100mL

Blast Off Endurance 20mL may increase the force of heart muscle contraction, thereby increasing blood flow and oxygen to the muscles in Race Horses, Greyhounds, Dogs & Camels by providing L-Carnitine, L-Carnosine, and Beta Alanine.

COMPOSITION:
100MG/ML – L-CARNOSINE
100MG/ML – L-CARNITINE
300MG/ML – BETA ALANINE

ACTIONS:
Blast Off Endurance may increase stamina by providing essential vitamins and amino acids to the muscles.

 

INDICATIONS:

-To improve energy and oxygen supply to muscles

-Increase maximum oxygen uptake and power output

-Delay the onset of fatigue and promote muscle recovery in performance race horses, dogs, greyhounds, alpacas
-Increase endurance and stamina

FOR: Race Horses, Greyhounds, Dogs, Camels

DOSAGE & ADMINISTRATION:

20ml given 4-6hrs prior to anticipated exercise

PRESENTATION: 20 mL sterile glass vial.

STORAGE: Store below 25 C (Air Conditioning)

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Blast Off Yellow 10mL

Blast Off Yellow Injection 10mL

Blast Off Yellow Injection

 

All in one prerace developed to increase endurance, provide and immediate source of energy, transport oxygen to muscles, and stop lactic acid build up to maximize muscle strength.

If your trying to gain maximum performance from your animal then this is the product for you.

Give 10ml 4-6 hrs before anticipate exercise

For: Horses, Dogs / Greyhounds, Camels

Form: 10ml sterile glass vial

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Best Horse Supplement

Best Horse Supplement

What is Pentosan Platinum? Pentosan Platinum contains the naturally occurring components of synovia that play a central role in maintaining the homeostatic environment of the joint.

Who is it for? Horses, Dogs, Greyhounds, Camels

Why use it? Pentosan Platinum is a formulation designed to replace synovial fluid lost during surgery and also as weekly IM injection to help with joint detioration from the stress of competition.

How it works? Glucosaminoglycans are important components of all extracellular tissue structures including cartilage and synovial fluid. The active components in Pentosan Platinum exhibit viscoelastic and polyionic properties similar in nature to synovial fluid.

Active ingredient(s): Pentosan 183mg/ml, Glucosamine 83mg/ml, Hyalronic Acid 3mg/ml

How is it sold? 18mL  Sterile glass vial

INDICATIONS- Non-infectious inflammatory joint disease, traumatic arthritis, degenerative cartilaginous joint disease, osteoarthritis and osteochondrosis dessicans in horses.

FORM- Sterile for injection

CATEGORY- Joint Supplements / Pain

What are the side effects? No known side effects

What to do if overdose? Contact your nearest emergency animal hospital.

How Can I store it? Store in a cool, dry place. Do not freeze.

DOSEAGE & ADMINISTRATION – Administer at a dose rate of 3 mg/kg bodyweight (1.5 g / 500 kg horse), by I.V use, at 5 – 7 day intervals for four doses. Pentosan Platinum is equally effective when given by I.V. or intra-articular injection. If intra-articular use is required, administer 1mL by sterile intra-articular injection. Pentosan Platinum has an affinity for cartilage, and active drug levels will accumulate for several days after administration. For maximum effect, tissues should be exposed to the drug over an extended period, hence the four injections. A period of improvement for up to 6 months following a course of four injections uses may be expected. If at any time during this period the horse becomes sore (e.g. following a particular activity), it is safe to administer a further injection to settle any inflammatory process.

Helpful Tips: This composition of supplements is very similar to Legend, Adequan and Polyglycan, plus Glucosamine

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

CLICK HERE TO BUY NOW

Best Horse Joint Supplement

Pentosan Platinum

What is Pentosan Platinum? Pentosan Platinum contains the naturally occurring components of synovia that play a central role in maintaining the homeostatic environment of the joint.

Who is it for? Horses, Dogs, Greyhounds, Camels

Why use it? Pentosan Platinum is a formulation designed to replace synovial fluid lost during surgery and also as weekly IM injection to help with joint detioration from the stress of competition.

How it works? Glucosaminoglycans are important components of all extracellular tissue structures including cartilage and synovial fluid. The active components in Pentosan Platinum exhibit viscoelastic and polyionic properties similar in nature to synovial fluid.

Active ingredient(s): Pentosan 183mg/ml, Glucosamine 83mg/ml, Hyalronic Acid 3mg/ml

How is it sold? 18mL  Sterile glass vial

INDICATIONS- Non-infectious inflammatory joint disease, traumatic arthritis, degenerative cartilaginous joint disease, osteoarthritis and osteochondrosis dessicans in horses.

FORM- Sterile for injection

CATEGORY- Joint Supplements / Pain

What are the side effects? No known side effects

What to do if overdose? Contact your nearest emergency animal hospital.

How Can I store it? Store in a cool, dry place. Do not freeze.

DOSEAGE & ADMINISTRATION – Administer at a dose rate of 3 mg/kg bodyweight (1.5 g / 500 kg horse), by I.V use, at 5 – 7 day intervals for four doses. Pentosan Platinum is equally effective when given by I.V. or intra-articular injection. If intra-articular use is required, administer 1mL by sterile intra-articular injection. Pentosan Platinum has an affinity for cartilage, and active drug levels will accumulate for several days after administration. For maximum effect, tissues should be exposed to the drug over an extended period, hence the four injections. A period of improvement for up to 6 months following a course of four injections uses may be expected. If at any time during this period the horse becomes sore (e.g. following a particular activity), it is safe to administer a further injection to settle any inflammatory process.

Helpful Tips: This composition of supplements is very similar to Legend, Adequan and Polyglycan, plus Glucosamine

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

CLICK HERE TO BUY NOW

Best Equine Joint Supplement

Best Equine Joint Supplement

What is Pentosan Platinum? Horse Joint Supplement contains the naturally occurring components of synovia that play a central role in maintaining the homeostatic environment of the joint.

Who is it for? Horses, Dogs, Greyhounds, Camels

Why use it? Pentosan Platinum is a formulation designed to replace synovial fluid lost during surgery and also as weekly IM injection to help with joint detioration from the stress of competition.

How it works? Glucosaminoglycans are important components of all extracellular tissue structures including cartilage and synovial fluid. The active components in Pentosan Platinum exhibit viscoelastic and polyionic properties similar in nature to synovial fluid.

Active ingredient(s): Pentosan 183mg/ml, Glucosamine 83mg/ml, Hyalronic Acid 3mg/ml

How is it sold? 18mL  Sterile glass vial

INDICATIONS- Non-infectious inflammatory joint disease, traumatic arthritis, degenerative cartilaginous joint disease, osteoarthritis and osteochondrosis dessicans in horses.

FORM- Sterile for injection

CATEGORY- Joint Supplements / Pain

What are the side effects? No known side effects

What to do if overdose? Contact your nearest emergency animal hospital.

How Can I store it? Store in a cool, dry place. Do not freeze.

DOSEAGE & ADMINISTRATION – Administer at a dose rate of 3 mg/kg bodyweight (1.5 g / 500 kg horse), by I.V use, at 5 – 7 day intervals for four doses. Pentosan Platinum is equally effective when given by I.V. or intra-articular injection. If intra-articular use is required, administer 1mL by sterile intra-articular injection. Pentosan Platinum has an affinity for cartilage, and active drug levels will accumulate for several days after administration. For maximum effect, tissues should be exposed to the drug over an extended period, hence the four injections. A period of improvement for up to 6 months following a course of four injections uses may be expected. If at any time during this period the horse becomes sore (e.g. following a particular activity), it is safe to administer a further injection to settle any inflammatory process.

Helpful Tips: This composition of supplements is very similar to Legend, Adequan and Polyglycan, plus Glucosamine

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

CLICK HERE TO BUY NOW

Bayer Baycox

Bayer Baycox

Toltrazuril (Compare to the active ingredients of Baycox 5%®) is the result of research efforts to help treat EPM. Thanks to its characteristics, it represents a new standard in coccidiosis control in Race Horses, Camels, Pigeons, Greyhounds & Alpacas.

Toltrazuril (Compare to the active ingredients of Baycox 5% ®) belongs to the chemical group of €œsymmetric triazinons€ and is not chemically related to any other anticoccidial drug currently used in veterinary medicine. This is a 5% solution.

Due to its particular mode of action, which affects all intracellular structures of Coccidia, Toltrazuril (Compare the active ingredient of Baycox 5% ®)demonstrates very high efficacy, as shown by the following benefits:

-prevents or reduces the severity of lesions,
-stops oocyst shedding,
-improves growth rate,
-improves feed conversion.

These product characteristics make Baycox 5% ® suitable for both therapy and metaphylaxis in domesticated animals.

Toltrazuril (Compare the active ingredient of Baycox 5% ®)represents a very important tool in the control of coccidia problems.

Toltrazuril (Compare the active ingredient of Baycox 5% ®) damages all intracellular development stages of Eimeria (= Coccidia).

Toltrazuril affects schizonts, micro- and macrogametes, but not the tissue cells of the host animals, as was shown in light and electron microscopic studies.

These findings suggest that toltrazuril interferes with the division of the nucleus and with the activity of the mitochondria, which is responsible for the respiratory metabolism of Coccidia.

In the magrometes, toltrazuril damages the so-called wall-forming bodies. In all intracellular developmental stages, severe vacuolisation occurs due to inflation of the endoplasmatic reticulum.

Toltrazuril thus has a coccidiocidal mode of action.

The special mode of action results in the following advantages:

-toltrazuril acts on all intracellular developmental stages,
-toltrazuril does not interfere with the development of immunity,
-follow-up treatment usually is not necessary,
-even an advanced infection (after 3 €“ 5 days; gametogony) can still be treated successfully,
-the efficacy of toltrazuril is independent of the severity of the infection.

Notes:

Toltrazuril (Compare to the active ingredients of Baycox 5%®) is a new treatment that may actually cure coccidiosis, instead of just suppressing it. The drug is available in  Canada and Australia, but not the US. Albon and Tribrissen are used for years to control coccidia infection, but these drugs don’t cure it and the animal may continue to shed spores (remain infectious to other animals). Marquis paste is made from a similar drug, ponazuril, which is a metabolite of toltrazuril.

DO NOT use the 2.5% solution sold as a pigeon remedy, as it can be caustic to the mucus membranes of cats.

Do not use this drug in pregnant cats as the terratogenic effects of this drug has not been adequately researched as yet.

The dose of Toltrazuril (Compare to the active ingredients of Baycox 5%®) is 20 mg/kg (10 mg per pound). This is 0.2 ml per pound of cat when using the 5% suspension. In a published study, a single dose of Toltrazuril (Compare to the active ingredients of Baycox 5%®) cured coccidiosis in puppies, as long as adequate environmental clean-up is performed. However, I’d recommend repeating it weekly for a couple of weeks. Clean up of the environment is critical to get rid of coccidia. This drug works best when it is used at the age of 4-6 weeks to PREVENT coccidia infection in kittens.

An alternative to Toltrazuril (Compare to the active ingredients of Baycox 5%®) is the similar drug ponazuril, marketed as Marquis paste for horses. The dose is 20mg/kg once a day for 1-3 days. The paste contains 150mg ponazuril per gram of paste. The plunger is marked for horses weighing 600 – 1200 pounds. You want to take the amount for a 600# horse and dilute it to a total volume of 14 ml in something tasty. Dose at 0.1 ml per pound of cat. Discard the unused volume.

Here is the journal abstract I posted to the Fanciershealth Yahoogroups list in 2001: Toltrazuril treatment of cystoisosporosis in dogs under experimental and field conditions. A Daugschies, HC Mundt, V Letkova Parasitology Research, 2000, Vol 86, Iss 10, pp 797-799

Coccidia of the genus Cystoisospora cause mild to severe diarrhoea in dogs. The effects of toltrazuril treatment on cystoisosporosis were studied under experimental and field conditions. Twenty-four puppies were experimentally infected each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. Three groups of six puppies were treated 3 dpi with 10, 20 or 30 mg/kg body weight of toltrazuril suspension (5%); the remaining six puppies served as non-treated controls. Toltrazuril suspension or microgranulate were given once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Oocyst excretion and clinical data were recorded.

Under experimental conditions, the non-treated puppies excreted oocysts beginning at 6 dpi and suffered from catarrhalic to haemorrhagic diarrhoea. On 12 dpi, four of six non-treated puppies died. Irrespective of the dose, toltrazuril treatment totally suppressed oocyst excretion and no diarrhoea or other signs of disease were observed in the treated groups. Natural Cystoisospora infections were regularly found during the 3rd or 4th week of age in dog breeding facilities although not always associated with diarrhoea. A single oral application of toltrazuril abrogated oocyst shedding and the treated puppies remained generally coproscopically negative during the following 2-4 weeks.

Cystoisospora is pathogenic for puppies and can induce severe disease. Natural infections are common in conventional dog breeding facilities. Toltrazuril treatment is suitable for controlling cystoisosporosis under experimental and field conditions. A single oral treatment for puppies in the 3rd/4th week of age is recommended.

Here is some information directly from Dr. Bruce Kilmer at Bayer Canada:

The drug active is toltrazuril, which has a cidal mode of action on protozoan. The toltrazuril will kill all single cell stages of coccidiosis. Once an animal has diarrhea and you can find oocysts on fecals, the drug can not penetrate the oocysts so technically it is too late to treat. In the actual clinical cases, treatment is still worthwhile to shorten the length and severity of the diarrhea as there is still development of the life cycle in the small intestine that will be controlled.

The idea is to dose the cat before there are clinical signs. For example, the normal situation would be a cattery having regular problems with coccidiosis in young kittens. The kittens normally would break with diarrhea at about 5 weeks of age. The treatment would be given around day 28, killing the early stages of the protozoa and preventing clinical disease. You will not have the history on a rescue cat so treatment would be best at the earliest hint of an outbreak and then repeat treatment in 7 days.

Toltrazuril (Compare to the active ingredients of Baycox 5%®) treatment will not cause sloughing of the intestinal epithelial cells. The coccidiosis does a fine job of that on its own. We have electron micrograph studies of sections of intestine 24 hours post treatment with Toltrazuril (Compare to the active ingredients of Baycox 5%®). The intestinal cells remain intact and functional while the single cell stages of the cocci are dead, as evidenced by staining techniques. because Toltrazuril (Compare to the active ingredients of Baycox 5%®) is cidal, the kitten does not have to depend on its immune system to eliminate the cocci as what would occur with a static drug like sulfadimethoxine.

Remember that Toltrazuril (Compare to the active ingredients of Baycox 5%®) should be given during the preclinical stage. This is very difficult to judge as the kitten will be at a stage when it is infected but the cocci are only in the first stages of their life cycle. The intent is to kill the protozoa before there is damage to the villi to clear the infection. In this way, the kittens will not develop the normal clinical signs of diarrhea. If you can identify oocysts on fecal exam, the damage has already been done and the protozoa has completed its reproductive cycle. Drug can not penetrate the oocyst wall to kill this stage. Treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril (Compare to the active ingredients of Baycox 5%®) will kill the single cell stages that have not reproduced sexually yet.

Try to determine the usual age that you see outbreaks. For example, many catteries will see diarrhea sometime around day 35. The time to treat is therefore at day 28. Likely the kittens had an infective dose of oocysts by this stage but minimal damage has occurred. Treatment will eliminate the coccidiosis before there is damage and the kittens will not break with diarrhea. Studies in other species indicate that the animal will have developed immunity to subsequent exposure.

The dose is 20 mg/kg by oral dosing.

Toltrazuril is quite lipid soluble so absorption and distribution into tissue is very good. Toltrazuril (Compare to the active ingredients of Baycox 5%®) has a unique mode of action and there is no reason to be concerned with an adverse reaction or a drug-drug reaction. We have never had an adverse reaction reported after millions of treatments, often concurrent with other medications.

I have never heard of any adverse reactions to treatment at this dose in puppies or kittens or on the repeat seven days later. As Toltrazuril (Compare to the active ingredients of Baycox 5%®) only has activity against protozoa, there is no effect on upset of intestinal flora and the formulation is very well tolerated. The only time I have heard of any reaction occurred when someone used the Toltrazuril (Compare to the active ingredients of Baycox 5%®) 2.5% Poultry Concentrate by direct oral dosing in 3 day old piglets. This formulation is designed to be diluted in the drinking water for poultry. To be soluble in water, the product undiluted is very alkaline, pH 11.4. Direct oral dosing of the undiluted product is very irritating to mucous membranes and will cause immediate vomiting. Make sure you are using the correct formulation.

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

CLICK HERE TO BUY NOW

Baycox Toltrazuril

Baycox Toltrazuril

Toltrazuril (Compare to the active ingredients of Baycox 5%®) is the result of research efforts to help treat EPM. Thanks to its characteristics, it represents a new standard in coccidiosis control in Race Horses, Camels, Pigeons, Greyhounds & Alpacas.

Toltrazuril (Compare to the active ingredients of Baycox 5% ®) belongs to the chemical group of €œsymmetric triazinons€ and is not chemically related to any other anticoccidial drug currently used in veterinary medicine. This is a 5% solution.

Due to its particular mode of action, which affects all intracellular structures of Coccidia, Toltrazuril (Compare the active ingredient of Baycox 5% ®)demonstrates very high efficacy, as shown by the following benefits:

-prevents or reduces the severity of lesions,
-stops oocyst shedding,
-improves growth rate,
-improves feed conversion.

These product characteristics make Baycox Bayer suitable for both therapy and metaphylaxis in domesticated animals.

Toltrazuril (Compare the active ingredient of Baycox 5% ®)represents a very important tool in the control of coccidia problems.

Toltrazuril (Compare the active ingredient of Baycox 5% ®) damages all intracellular development stages of Eimeria (= Coccidia).

Toltrazuril affects schizonts, micro- and macrogametes, but not the tissue cells of the host animals, as was shown in light and electron microscopic studies.

These findings suggest that toltrazuril interferes with the division of the nucleus and with the activity of the mitochondria, which is responsible for the respiratory metabolism of Coccidia.

In the magrometes, toltrazuril damages the so-called wall-forming bodies. In all intracellular developmental stages, severe vacuolisation occurs due to inflation of the endoplasmatic reticulum.

Toltrazuril thus has a coccidiocidal mode of action.

The special mode of action results in the following advantages:

-toltrazuril acts on all intracellular developmental stages,
-toltrazuril does not interfere with the development of immunity,
-follow-up treatment usually is not necessary,
-even an advanced infection (after 3 €“ 5 days; gametogony) can still be treated successfully,
-the efficacy of toltrazuril is independent of the severity of the infection.

Notes:

Toltrazuril (Compare to the active ingredients of Baycox 5%®) is a new treatment that may actually cure coccidiosis, instead of just suppressing it. The drug is available in  Canada and Australia, but not the US. Albon and Tribrissen are used for years to control coccidia infection, but these drugs don’t cure it and the animal may continue to shed spores (remain infectious to other animals). Marquis paste is made from a similar drug, ponazuril, which is a metabolite of toltrazuril.

DO NOT use the 2.5% solution sold as a pigeon remedy, as it can be caustic to the mucus membranes of cats.

Do not use this drug in pregnant cats as the terratogenic effects of this drug has not been adequately researched as yet.

The dose of Toltrazuril (Compare to the active ingredients of Baycox 5%®) is 20 mg/kg (10 mg per pound). This is 0.2 ml per pound of cat when using the 5% suspension. In a published study, a single dose of Toltrazuril (Compare to the active ingredients of Baycox 5%®) cured coccidiosis in puppies, as long as adequate environmental clean-up is performed. However, I’d recommend repeating it weekly for a couple of weeks. Clean up of the environment is critical to get rid of coccidia. This drug works best when it is used at the age of 4-6 weeks to PREVENT coccidia infection in kittens.

An alternative to Toltrazuril (Compare to the active ingredients of Baycox 5%®) is the similar drug ponazuril, marketed as Marquis paste for horses. The dose is 20mg/kg once a day for 1-3 days. The paste contains 150mg ponazuril per gram of paste. The plunger is marked for horses weighing 600 – 1200 pounds. You want to take the amount for a 600# horse and dilute it to a total volume of 14 ml in something tasty. Dose at 0.1 ml per pound of cat. Discard the unused volume.

Here is the journal abstract I posted to the Fanciershealth Yahoogroups list in 2001: Toltrazuril treatment of cystoisosporosis in dogs under experimental and field conditions. A Daugschies, HC Mundt, V Letkova Parasitology Research, 2000, Vol 86, Iss 10, pp 797-799

Coccidia of the genus Cystoisospora cause mild to severe diarrhoea in dogs. The effects of toltrazuril treatment on cystoisosporosis were studied under experimental and field conditions. Twenty-four puppies were experimentally infected each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. Three groups of six puppies were treated 3 dpi with 10, 20 or 30 mg/kg body weight of toltrazuril suspension (5%); the remaining six puppies served as non-treated controls. Toltrazuril suspension or microgranulate were given once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Oocyst excretion and clinical data were recorded.

Under experimental conditions, the non-treated puppies excreted oocysts beginning at 6 dpi and suffered from catarrhalic to haemorrhagic diarrhoea. On 12 dpi, four of six non-treated puppies died. Irrespective of the dose, toltrazuril treatment totally suppressed oocyst excretion and no diarrhoea or other signs of disease were observed in the treated groups. Natural Cystoisospora infections were regularly found during the 3rd or 4th week of age in dog breeding facilities although not always associated with diarrhoea. A single oral application of toltrazuril abrogated oocyst shedding and the treated puppies remained generally coproscopically negative during the following 2-4 weeks.

Cystoisospora is pathogenic for puppies and can induce severe disease. Natural infections are common in conventional dog breeding facilities. Toltrazuril treatment is suitable for controlling cystoisosporosis under experimental and field conditions. A single oral treatment for puppies in the 3rd/4th week of age is recommended.

Here is some information directly from Dr. Bruce Kilmer at Bayer Canada:

The drug active is toltrazuril, which has a cidal mode of action on protozoan. The toltrazuril will kill all single cell stages of coccidiosis. Once an animal has diarrhea and you can find oocysts on fecals, the drug can not penetrate the oocysts so technically it is too late to treat. In the actual clinical cases, treatment is still worthwhile to shorten the length and severity of the diarrhea as there is still development of the life cycle in the small intestine that will be controlled.

The idea is to dose the cat before there are clinical signs. For example, the normal situation would be a cattery having regular problems with coccidiosis in young kittens. The kittens normally would break with diarrhea at about 5 weeks of age. The treatment would be given around day 28, killing the early stages of the protozoa and preventing clinical disease. You will not have the history on a rescue cat so treatment would be best at the earliest hint of an outbreak and then repeat treatment in 7 days.

Toltrazuril (Compare to the active ingredients of Baycox 5%®) treatment will not cause sloughing of the intestinal epithelial cells. The coccidiosis does a fine job of that on its own. We have electron micrograph studies of sections of intestine 24 hours post treatment with Toltrazuril (Compare to the active ingredients of Baycox 5%®). The intestinal cells remain intact and functional while the single cell stages of the cocci are dead, as evidenced by staining techniques. because Toltrazuril (Compare to the active ingredients of Baycox 5%®) is cidal, the kitten does not have to depend on its immune system to eliminate the cocci as what would occur with a static drug like sulfadimethoxine.

Remember that Toltrazuril (Compare to the active ingredients of Baycox 5%®) should be given during the preclinical stage. This is very difficult to judge as the kitten will be at a stage when it is infected but the cocci are only in the first stages of their life cycle. The intent is to kill the protozoa before there is damage to the villi to clear the infection. In this way, the kittens will not develop the normal clinical signs of diarrhea. If you can identify oocysts on fecal exam, the damage has already been done and the protozoa has completed its reproductive cycle. Drug can not penetrate the oocyst wall to kill this stage. Treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril (Compare to the active ingredients of Baycox 5%®) will kill the single cell stages that have not reproduced sexually yet.

Try to determine the usual age that you see outbreaks. For example, many catteries will see diarrhea sometime around day 35. The time to treat is therefore at day 28. Likely the kittens had an infective dose of oocysts by this stage but minimal damage has occurred. Treatment will eliminate the coccidiosis before there is damage and the kittens will not break with diarrhea. Studies in other species indicate that the animal will have developed immunity to subsequent exposure.

The dose is 20 mg/kg by oral dosing.

Toltrazuril is quite lipid soluble so absorption and distribution into tissue is very good. Toltrazuril (Compare to the active ingredients of Baycox 5%®) has a unique mode of action and there is no reason to be concerned with an adverse reaction or a drug-drug reaction. We have never had an adverse reaction reported after millions of treatments, often concurrent with other medications.

I have never heard of any adverse reactions to treatment at this dose in puppies or kittens or on the repeat seven days later. As Toltrazuril (Compare to the active ingredients of Baycox 5%®) only has activity against protozoa, there is no effect on upset of intestinal flora and the formulation is very well tolerated. The only time I have heard of any reaction occurred when someone used the Toltrazuril (Compare to the active ingredients of Baycox 5%®) 2.5% Poultry Concentrate by direct oral dosing in 3 day old piglets. This formulation is designed to be diluted in the drinking water for poultry. To be soluble in water, the product undiluted is very alkaline, pH 11.4. Direct oral dosing of the undiluted product is very irritating to mucous membranes and will cause immediate vomiting. Make sure you are using the correct formulation.

For use as a supplemental source of Vitamins & Amino Acids in horses, cattle, sheep, swine camels, alpacas, and pigeons.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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